Tesamorelin

Tesamorelin 10mg

Tesamorelin is a high-purity, synthetic 44-amino acid peptide analog of human growth hormone-releasing hormone (GHRH). This peptide incorporates a trans-3-hexenoyl moiety at the N-terminus to enhance stability, resistance to enzymatic degradation, and pharmacokinetic properties compared to native GHRH. These modifications allow for potent stimulation of the pituitary gland, promoting endogenous growth hormone (GH) release and subsequent elevation of insulin-like growth factor-1 (IGF-1) levels, making it an essential compound for endocrine and metabolic research.

At M5 Research Peptides, our tesamorelin is lyophilized in 10mg vials, providing reliable and precise quantities for experimental protocols. Each batch is sourced and packaged under the oversight of our licensed pharmacist to uphold exceptional quality and consistency.

Key Research Applications

Tesamorelin has been widely investigated in preclinical and in vitro models for its effects on hormone regulation and body composition. Primary areas of study include:

• Growth Hormone Secretion and Endocrine Function: Research demonstrates tesamorelin's ability to bind GHRH receptors on pituitary somatotroph cells, activating adenylyl cyclase and increasing cAMP levels, which leads to pulsatile GH release. This is valuable for studying GH deficiencies and signaling pathways.
• Visceral Adipose Tissue Reduction: Studies in models of lipodystrophy, such as those mimicking HIV-associated conditions, show tesamorelin reduces excess abdominal fat through enhanced lipolysis while preserving lean mass, offering insights into fat metabolism and redistribution.
• Metabolic Disorders and Insulin Sensitivity: Experimental data indicate improvements in glucose homeostasis, lipid profiles, and energy expenditure, relevant to investigations of obesity, non-alcoholic fatty liver disease (NAFLD), and type 2 diabetes models.
• Aging and Cognitive Research: Preliminary studies explore tesamorelin's role in mitigating age-related GH decline, potentially influencing cognitive function, muscle maintenance, and overall metabolic health in geriatric models.
• Body Composition and Anabolic Effects: In cellular and animal assays, tesamorelin supports lean muscle preservation and fat loss, aiding research into anabolic pathways and body weight management.

These applications are backed by peer-reviewed literature, including clinical pharmacology data and structural analyses, distinguishing tesamorelin from other GHRH analogs.

Quality Assurance

• Purity: >99% as confirmed by independent HPLC and mass spectrometry from U.S.-accredited laboratories like Eurofins BioPharma.
• Form: Sterile, lyophilized powder suitable for reconstitution with bacteriostatic water or appropriate buffers.

Storage and Handling Instructions

• Store unopened vials at -20°C for optimal long-term stability (up to 24 months).
• After reconstitution, refrigerate at 2-8°C and utilize within 28 days to maintain efficacy.
• Minimize freeze-thaw cycles and protect from direct sunlight.

M5 Research Peptides dedicates itself to supplying superior research-grade peptides, supported by expert pharmacist involvement in procurement, testing, and regulatory adherence. Our products are designed to facilitate groundbreaking scientific exploration.

Important Disclaimer: This product is designated exclusively for laboratory research purposes and is not intended for human or animal administration. It lacks FDA approval for therapeutic applications. Adhere to all relevant legal and institutional protocols. M5 Research Peptides disclaims responsibility for any improper use. Review safety data sheets prior to experimentation.