Cagrilintide

Cagrilintide 10mg

Cagrilintide is a high-purity, synthetic peptide analog of amylin, designed as a long-acting agonist for amylin and calcitonin receptors. This peptide features targeted structural modifications, including an N-terminal C20 fatty acid for extended half-life, amino acid substitutions such as Asn14Glu and Val17Arg for enhanced solubility and helix stabilization, and proline replacements at positions 25, 28, and 29 to minimize amyloid fibril formation. These alterations improve its stability and pharmacokinetic profile compared to native amylin, making it a valuable tool for in vitro and in vivo studies.

At M5 Research Peptides, our cagrilintide is lyophilized in 10mg vials, ensuring precise dosing for laboratory applications. Each batch is meticulously sourced and packaged under the direct supervision of our licensed pharmacist to maintain the highest standards of quality and integrity.

Key Research Applications

Cagrilintide has been extensively studied in preclinical and experimental models for its potential roles in metabolic regulation. Notable areas of investigation include:

• Appetite and Satiety Signaling: Research explores how cagrilintide interacts with amylin receptors (AMY1R, AMY2R, AMY3R) and calcitonin receptors to modulate food intake, promoting feelings of fullness and reducing caloric consumption in animal models.
• Glucose Homeostasis and Metabolic Disorders: Studies investigate its effects on postprandial glucose levels, insulin co-secretion, and energy balance, providing insights into mechanisms relevant to diabetes and obesity models.
• Body Weight Management: Experimental data from rodent and cellular assays demonstrate cagrilintide's ability to reduce body weight by targeting fat mass while preserving lean mass, through central nervous system pathways involving brain amylin receptors.
• Gastric Emptying and Digestion: Investigations focus on its influence on gastrointestinal motility, offering a platform to study digestive physiology and related disorders.
• Receptor Pharmacology and Dynamics: Cryo-electron microscopy and binding assays have revealed detailed structural interactions, aiding in the development of novel agonists for endocrine research.

These applications are supported by peer-reviewed studies, including structural analyses via cryo-EM and phase trials data, highlighting cagrilintide's unique profile compared to other amylin analogs like pramlintide.

Quality Assurance

• Purity: >99% as verified by third-party HPLC and mass spectrometry testing from accredited U.S.-based labs, such as Eurofins BioPharma.
• Form: Sterile, lyophilized powder for reconstitution with bacteriostatic water or suitable solvents.

Storage and Handling Instructions

• Store unopened vials at -20°C for long-term stability (up to 24 months).
• Once reconstituted, keep refrigerated at 2-8°C and use within 28 days to preserve potency.
• Avoid repeated freeze-thaw cycles and exposure to direct light.

M5 Research Peptides is committed to providing premium, research-grade compounds backed by pharmacist expertise in sourcing, quality control, and compliance. All products undergo rigorous testing to ensure consistency and reliability for your scientific endeavors.

Important Disclaimer: This product is intended strictly for laboratory research use only and is not for human or veterinary consumption. It is not approved by the FDA for any therapeutic purposes. Users must comply with all applicable laws and regulations. M5 Research Peptides assumes no liability for misuse. Consult institutional guidelines before handling.